What is the use and synthesis method of 2-aminothiazole?

2-Aminothiazole is a white or light yellow crystal with a melting point of 93°C and a boiling point of 140°C (1.47kPa). It is soluble in hot water, dilute hydrochloric acid and 20% sulfuric acid, and slightly soluble in cold water, ethanol and ether. It is an important chemical raw material and a synthetic intermediate for medicines, dyes, water purifiers, etc. It is widely used in the synthesis of third and fourth generation cephalosporins.

Uses of 2-Aminothiazole:

1. Used as a pharmaceutical intermediate. Used in organic synthesis;

2. Mainly used in the synthesis of Nitrosulfathiazole, Sulfathiazole, Sulfasuxidinum, Carbothiazol, Phthalylsulfathiazole, Oxyquinolinephthalysulfathiazole, Salazosulfathiazole (Salazosulfathiazole);

3. It is used for gentle Ulmann coupling reaction with 2-chlorobenzoic acid under the guidance of ultrasonic radiation;

4. Used as intermediates of medicine and dyestuffs in Medical Chemicalbook.

2-aminothiazole

Production method of 2-aminothiazole:

2-Aminothiazole is obtained by cyclization of thiourea and chloroacetaldehyde (or ethanol and chlorine, or α, β dichloro ethyl ether). Add hot water, thiourea and α, β-dichloroethyl ether to the reactor. Reflux for 2h under stirring. After cooling, sodium hydroxide solution was added through the dropping funnel to make the solution alkaline and 2-aminothiazole crystals were precipitated. Then add ether to dissolve it. Separate the ether layer, wash with water, dry with anhydrous sodium sulfate, and distill the ether to obtain a crude product. Recrystallize with ethanol to obtain yellow crystals. The yield is 80%, and the melting point is 90°C.

2-Aminothiazole storage method:

2-Aminothiazole needs to be stored in a cool, ventilated warehouse. Keep away from fire and heat sources. Keep the container tightly closed. It should be stored separately from oxidants, acids, and edible chemicals, and avoid mixed storage. Equipped with the appropriate variety and quantity of fire equipment. The storage area should be equipped with suitable materials to contain the leakage.

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