If a patient suffers from a mental health disorder such as depression or anxiety or a physical condition such as chronic pain, these symptoms could be amplified due to withdrawal and cause significant distress. Daily use for an extended period of time can cause lead to high levels of tolerance and more severe withdrawal symptoms. Withdrawal from opioids and other substances can be associated with severe depressive symptoms that might be connected to suicide attempts and completed suicides.

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https://www.supplementz.org/pt-trim/