In situ Hybridization Market in terms of revenue was estimated to be worth $1.5 billion in 2022 and is poised to reach $2.8 billion by 2027, growing at a CAGR of 12.6% from 2022 to 2027. An increase in the adoption of in situ hybridization (ISH) products in managing genetic disorders and cancer patients is set to drive market growth. Emerging economies offer significant opportunities for key market players looking to strengthen their presence. In developed countries, high-quality molecular diagnostic tests are readily available. As a result, emerging markets such as India, China, and Brazil offer significant growth opportunities for MDx-based technology (including ISH) owing to the rising geriatric population, the growing prevalence of infectious diseases, and various types of cancer.

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Key Market Players

The market for in situ hybridization is competitive and highly consolidated, with key players strategizing to capture the market. Prominent players in the ISH market are Abbott (US), Thermo Fisher Scientific (US), Danaher Corporation (US), Merck KGaA (US), F. Hoffmann-La Roche AG (US), BioView (Israel), Agilent Technologies (US), Biocare Medical (US), Bio-Techne Corporation (US), QIAGEN N.V. (Germany), PerkinElmer (US), Enzo Biochem (US), Bio-Rad Laboratories (US), Abnova Corporation (Taiwan), BioGenex Laboratories (US), OpGen US), Bio SB (US), GeneMed Biotechnologies (US), Abcam plc. (UK), Creative Bioarray (US), BioCat GmbH (Spain), ZytoVision (Germany), NeoGenomics Laboratories (US), and Oxford Gene Technology (UK).

Key drivers of the in situ hybridization market include rising incidence of genetic disorders and cancer, and growing awareness of companion diagnostics. However, a shortage of skilled professionals poses a significant challenge to the growth of this market.

Driver: Rising incidence of genetic disorders and cancer

Over the years, there has been an increase in the incidence of cancer worldwide. Over the last two decades, extensive studies related to human diseases have recognized recurrent genomic abnormalities as potential driving factors for various cancers. Cytogenetic assays such as ISH help integrate IHC and DNA FISH to complete the in situ tool-set for researchers to discover, develop, and implement new-generation diagnostic procedures. Directly imaging gene expression in situ at the RNA level delivers a unique insight into the interplay between cancer cells and the tumor microenvironment while cancer progresses. A similar pattern is also followed for genetic disorders.

The FISH segment dominates the in situ hybridization (ISH) market through 2020-2027.

The global in situ hybridization market is segmented into product, technology, application, end user, and region. FISH uses fluorescently labeled DNA probes to detect or confirm the presence of genes or chromosomal abnormalities. It is also used in clinical research for the prenatal diagnosis of inherited chromosomal aberrations and postnatal diagnosis of carriers of genetic diseases. FISH is considered more reliable, sensitive, and accurate as compared to IHC; moreover, this test does not require expensive equipment.

In 2021, the hospitals and diagnostic laboratories ranked first in terms of revenue in the in situ hybridization market.

Based on end users, the global in situ hybridization market is segmented into hospitals and diagnostic laboratories, academic research institutes, contract research organizations (CROs), and pharmaceutical biotechnology companies. In 2021, the hospitals and diagnostic laboratories segment accounted for the largest share of the in situ hybridization market, due to an increasing number of molecule-based screenings, the increasing number of specialty diagnostic tests performed in hospital laboratories, the rising number of in-house diagnostic procedures, and the rising trend of establishing in-house diagnostic capabilities in hospitals.

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The Asia Pacific region is the fastest-growing region of the in situ hybridization market in 2021.

The Asia Pacific region is estimated to grow at the highest CAGR in the in situ hybridization market during the forecast period. China and India are the key revenue contributors to the Asia Pacific in situ hybridization market. Favorable government support for product approvals and the presence of major players in these countries are anticipated to drive regional market growth.

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